IIrc 2*s should not be levelled above level 4 if you want to stay efficient. So by mergeing 2x 2*s you're done.
3*s can be levelled to level 10 or so with efficiency maintained.
4*s level 15 I think?
But don't take my word for it. The info is available on the forums, get creative with the search function and you will find it.